Snps in the fcer1a gene region show no association with allergic rhinitis in a han chinese population

Yuan Zhang, Su Duan, Xiaoping Lin, Wei Zhang, Na Meng, Liping Zhao, Yan Zhao, Demin Han, Luo Zhang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. Methodology/Principal Findings: A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. Conclusions: Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility.

Original languageEnglish (US)
Article numbere15792
JournalPloS one
Volume5
Issue number12
DOIs
StatePublished - Dec 1 2010

Fingerprint

immunoglobulin E
rhinitis
Immunoglobulin E
Genes
Polymorphism
Single Nucleotide Polymorphism
single nucleotide polymorphism
Population
Nucleotides
genes
blood serum
atopy
Serum
IgE Receptors
Gene encoding
Allergic Rhinitis
Allergens
allergens
clinical examination
Blood

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Zhang, Yuan ; Duan, Su ; Lin, Xiaoping ; Zhang, Wei ; Meng, Na ; Zhao, Liping ; Zhao, Yan ; Han, Demin ; Zhang, Luo. / Snps in the fcer1a gene region show no association with allergic rhinitis in a han chinese population. In: PloS one. 2010 ; Vol. 5, No. 12.
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abstract = "Background: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. Methodology/Principal Findings: A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. Conclusions: Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility.",
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Zhang, Y, Duan, S, Lin, X, Zhang, W, Meng, N, Zhao, L, Zhao, Y, Han, D & Zhang, L 2010, 'Snps in the fcer1a gene region show no association with allergic rhinitis in a han chinese population', PloS one, vol. 5, no. 12, e15792. https://doi.org/10.1371/journal.pone.0015792

Snps in the fcer1a gene region show no association with allergic rhinitis in a han chinese population. / Zhang, Yuan; Duan, Su; Lin, Xiaoping; Zhang, Wei; Meng, Na; Zhao, Liping; Zhao, Yan; Han, Demin; Zhang, Luo.

In: PloS one, Vol. 5, No. 12, e15792, 01.12.2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Snps in the fcer1a gene region show no association with allergic rhinitis in a han chinese population

AU - Zhang, Yuan

AU - Duan, Su

AU - Lin, Xiaoping

AU - Zhang, Wei

AU - Meng, Na

AU - Zhao, Liping

AU - Zhao, Yan

AU - Han, Demin

AU - Zhang, Luo

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. Methodology/Principal Findings: A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. Conclusions: Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility.

AB - Background: Immunoglobulin E (IgE) is a central player in the allergic response, and raised total IgE levels are considered as an indicator of atopy or potential development of atopy. A recent genome-wide scan in a German population-based cohort of adults identified the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) as a susceptibility locus influencing total serum IgE levels. The aim of this study was to investigate whether the polymorphisms in the FCER1A gene are associated with allergic rhinitis (AR) in a Han Chinese population. Methodology/Principal Findings: A population of 378 patients with AR and 288 healthy controls was studied. Precise phenotyping of patients was accomplished by means of a questionnaire and clinical examination. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE) measurement. A total of 16 single nucleotide polymorphisms (SNPs) in FCER1A were selected and individually genotyped. None of the SNPs in the FCER1A showed an association with AR. Similarly, the lack of association was also evident in subgroup analysis for the presence of different allergen sensitivities. None of the selected SNPs in FCER1A was associated with total IgE level. Conclusions: Although FCER1A presents itself as a good candidate for contributing to total serum IgE, this study failed to find an association between SNPs in the FCER1A gene region and IgE level or AR susceptibility.

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