Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures

Zhen Huang, Yee C. Chiew, Wei Dong Lu, S. Kawi

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO 2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol% methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng-Robinson equation of state model with an AARD ranging from 14 to 23%.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalFluid Phase Equilibria
Volume237
Issue number1-2
DOIs
StatePublished - Oct 25 2005

Fingerprint

Carbon Dioxide
Aspirin
carbon dioxide
Carbon dioxide
alcohols
Alcohols
solubility
Solubility
Methanol
Ethanol
ethyl alcohol
methyl alcohol
Saturation (materials composition)
organic solids
Molecular interactions
molecular interactions
Carbon Monoxide
Equations of state
solutes
equations of state

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Keywords

  • Alcohol
  • Aspirin
  • Peng-Robinson EOS
  • Solubility enhancement
  • Supercritical CO

Cite this

Huang, Zhen ; Chiew, Yee C. ; Lu, Wei Dong ; Kawi, S. / Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures. In: Fluid Phase Equilibria. 2005 ; Vol. 237, No. 1-2. pp. 9-15.
@article{4c35328381044260b2fd6b0969d41a41,
title = "Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures",
abstract = "The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO 2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol{\%} methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng-Robinson equation of state model with an AARD ranging from 14 to 23{\%}.",
keywords = "Alcohol, Aspirin, Peng-Robinson EOS, Solubility enhancement, Supercritical CO",
author = "Zhen Huang and Chiew, {Yee C.} and Lu, {Wei Dong} and S. Kawi",
year = "2005",
month = "10",
day = "25",
doi = "10.1016/j.fluid.2005.08.004",
language = "English (US)",
volume = "237",
pages = "9--15",
journal = "Fluid Phase Equilibria",
issn = "0378-3812",
publisher = "Elsevier",
number = "1-2",

}

Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures. / Huang, Zhen; Chiew, Yee C.; Lu, Wei Dong; Kawi, S.

In: Fluid Phase Equilibria, Vol. 237, No. 1-2, 25.10.2005, p. 9-15.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures

AU - Huang, Zhen

AU - Chiew, Yee C.

AU - Lu, Wei Dong

AU - Kawi, S.

PY - 2005/10/25

Y1 - 2005/10/25

N2 - The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO 2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol% methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng-Robinson equation of state model with an AARD ranging from 14 to 23%.

AB - The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO 2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol% methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng-Robinson equation of state model with an AARD ranging from 14 to 23%.

KW - Alcohol

KW - Aspirin

KW - Peng-Robinson EOS

KW - Solubility enhancement

KW - Supercritical CO

UR - http://www.scopus.com/inward/record.url?scp=26444611825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=26444611825&partnerID=8YFLogxK

U2 - 10.1016/j.fluid.2005.08.004

DO - 10.1016/j.fluid.2005.08.004

M3 - Article

AN - SCOPUS:26444611825

VL - 237

SP - 9

EP - 15

JO - Fluid Phase Equilibria

JF - Fluid Phase Equilibria

SN - 0378-3812

IS - 1-2

ER -