Solution NMR structures of homeodomains from human proteins ALX4, ZHX1, and CASP8AP2 contribute to the structural coverage of the Human Cancer Protein Interaction Network

Xianzhong Xu, Surya V.S.R.K. Pulavarti, Alexander Eletsky, Yuanpeng Janet Huang, Thomas B. Acton, Rong Xiao, John K. Everett, Gaetano T. Montelione, Thomas Szyperski

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved. These domains were chosen as targets of a biomedical theme project pursued by the Northeast Structural Genomics Consortium. This project focuses on increasing the structural coverage of human proteins associated with cancer.

Original languageEnglish (US)
Pages (from-to)201-207
Number of pages7
JournalJournal of Structural and Functional Genomics
Volume15
Issue number4
DOIs
StatePublished - Nov 20 2014

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Genetics

Keywords

  • Homeodomain
  • PF00046
  • Structural genomics
  • Transcription factor

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