Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network

Surya V.S.R.K. Pulavarti; Yuanpeng J. Huang; Kari Pederson; Thomas B. Acton; Rong Xiao; John K. Everett; James H. Prestegard; Gaetano T. Montelione; Thomas Szyperski

doi:10.1007/s10969-014-9185-y

Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network

Surya V.S.R.K. Pulavarti, Yuanpeng J. Huang, Kari Pederson, Thomas B. Acton, Rong Xiao, John K. Everett, James H. Prestegard, Gaetano T. Montelione, Thomas Szyperski

Research output: Contribution to journal › Article › peer-review

Abstract

High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein–protein interactions.

Original language	English (US)
Pages (from-to)	209-214
Number of pages	6
Journal	Journal of Structural and Functional Genomics
Volume	15
Issue number	4
DOIs	https://doi.org/10.1007/s10969-014-9185-y
State	Published - Nov 20 2014

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Genetics

Keywords

Cytoskeletal adapter
Ig-like domain
Obscurin-like protein 1
PF07679
Structural genomics

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10.1007/s10969-014-9185-y

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Pulavarti, S. V. S. R. K., Huang, Y. J., Pederson, K., Acton, T. B., Xiao, R., Everett, J. K., Prestegard, J. H., Montelione, G. T., & Szyperski, T. (2014). Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network. Journal of Structural and Functional Genomics, 15(4), 209-214. https://doi.org/10.1007/s10969-014-9185-y

@article{930934e60e914c158e277144d1bd9f02,

title = "Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network",

abstract = "High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein–protein interactions.",

keywords = "Cytoskeletal adapter, Ig-like domain, Obscurin-like protein 1, PF07679, Structural genomics",

author = "Pulavarti, {Surya V.S.R.K.} and Huang, {Yuanpeng J.} and Kari Pederson and Acton, {Thomas B.} and Rong Xiao and Everett, {John K.} and Prestegard, {James H.} and Montelione, {Gaetano T.} and Thomas Szyperski",

note = "Funding Information: Acknowledgments This work was supported by the National Institutes of Health, grant number: U54 GM094597 (T.S., J.H.P. and G.T.M.). Publisher Copyright: {\textcopyright} 2014, Springer Science+Business Media Dordrecht.",

year = "2014",

month = nov,

day = "20",

doi = "10.1007/s10969-014-9185-y",

language = "English (US)",

volume = "15",

pages = "209--214",

journal = "Journal of Structural and Functional Genomics",

issn = "1345-711X",

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number = "4",

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Pulavarti, SVSRK, Huang, YJ, Pederson, K, Acton, TB, Xiao, R, Everett, JK, Prestegard, JH, Montelione, GT & Szyperski, T 2014, 'Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network', Journal of Structural and Functional Genomics, vol. 15, no. 4, pp. 209-214. https://doi.org/10.1007/s10969-014-9185-y

Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network. / Pulavarti, Surya V.S.R.K.; Huang, Yuanpeng J.; Pederson, Kari et al.
In: Journal of Structural and Functional Genomics, Vol. 15, No. 4, 20.11.2014, p. 209-214.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network

AU - Pulavarti, Surya V.S.R.K.

AU - Huang, Yuanpeng J.

AU - Pederson, Kari

AU - Acton, Thomas B.

AU - Xiao, Rong

AU - Everett, John K.

AU - Prestegard, James H.

AU - Montelione, Gaetano T.

AU - Szyperski, Thomas

N1 - Funding Information: Acknowledgments This work was supported by the National Institutes of Health, grant number: U54 GM094597 (T.S., J.H.P. and G.T.M.). Publisher Copyright: © 2014, Springer Science+Business Media Dordrecht.

PY - 2014/11/20

Y1 - 2014/11/20

N2 - High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein–protein interactions.

AB - High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30 % sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein–protein interactions.

KW - Cytoskeletal adapter

KW - Ig-like domain

KW - Obscurin-like protein 1

KW - PF07679

KW - Structural genomics

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AN - SCOPUS:84911969171

SN - 1345-711X

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JO - Journal of Structural and Functional Genomics

JF - Journal of Structural and Functional Genomics

IS - 4

ER -

Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the human cancer protein interaction network

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