SOS induction and mutagenesis by dnaQ missense alleles in wild type cells

Satyendra Gautam, Raju Kalidindi, M. Zafri Humayun

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mistranslation leads to elevated mutagenesis and replication arrest, both of which are hypothesized to result from the presence of mixed populations of wild type and mistranslated versions of DNA polymerase III subunit proteins. Consistent with this possibility, expression of missense alleles of dnaQ (which codes for the proofreading subunit e{open}) in wild type (dnaQ+) cells is shown to lead to SOS induction as well as mutagenesis. Exposure to sublethal concentrations of streptomycin, an aminoglycoside antibiotic known to promote mistranslation, also leads to SOS induction.

Original languageEnglish (US)
Pages (from-to)46-50
Number of pages5
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume735
Issue number1-2
DOIs
StatePublished - Jul 1 2012

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Keywords

  • DNA replication
  • Mistranslation
  • Mutagenesis
  • Mutator
  • SOS induction
  • Streptomycin

Fingerprint Dive into the research topics of 'SOS induction and mutagenesis by dnaQ missense alleles in wild type cells'. Together they form a unique fingerprint.

Cite this