Spinal interneurons as gatekeepers to neuroplasticity after injury or disease

Lyandysha V. Zholudeva, Victoria E. Abraira, Kajana Satkunendrarajah, Todd C. McDevitt, Martyn D. Goulding, David S.K. Magnuson, Michael A. Lane

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.

Original languageEnglish (US)
Pages (from-to)845-854
Number of pages10
JournalJournal of Neuroscience
Issue number5
StatePublished - Feb 3 2021

All Science Journal Classification (ASJC) codes

  • Medicine(all)


  • Interneuron
  • Plasticity
  • Propriospinal
  • Spinal cord


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