Spinal interneurons as gatekeepers to neuroplasticity after injury or disease

Lyandysha V. Zholudeva; Victoria E. Abraira; Kajana Satkunendrarajah; Todd C. McDevitt; Martyn D. Goulding; David S.K. Magnuson; Michael A. Lane

doi:10.1523/JNEUROSCI.1654-20.2020

Spinal interneurons as gatekeepers to neuroplasticity after injury or disease

Lyandysha V. Zholudeva, Victoria E. Abraira, Kajana Satkunendrarajah, Todd C. McDevitt, Martyn D. Goulding, David S.K. Magnuson, Michael A. Lane

School of Arts and Sciences, Cell Biology & Neuroscience

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.

Original language	English (US)
Pages (from-to)	845-854
Number of pages	10
Journal	Journal of Neuroscience
Volume	41
Issue number	5
DOIs	https://doi.org/10.1523/JNEUROSCI.1654-20.2020
State	Published - Feb 3 2021

All Science Journal Classification (ASJC) codes

Medicine(all)

Keywords

Interneuron
Plasticity
Propriospinal
Spinal cord

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10.1523/JNEUROSCI.1654-20.2020

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abstract = "Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.",

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AU - Zholudeva, Lyandysha V.

AU - Abraira, Victoria E.

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AU - McDevitt, Todd C.

AU - Goulding, Martyn D.

AU - Magnuson, David S.K.

AU - Lane, Michael A.

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AB - Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.

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KW - Plasticity

KW - Propriospinal

KW - Spinal cord

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Spinal interneurons as gatekeepers to neuroplasticity after injury or disease

Abstract

All Science Journal Classification (ASJC) codes

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