Spinal interneurons as gatekeepers to neuroplasticity after injury or disease

Lyandysha V. Zholudeva, Victoria E. Abraira, Kajana Satkunendrarajah, Todd C. McDevitt, Martyn D. Goulding, David S.K. Magnuson, Michael A. Lane

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Spinal interneurons are important facilitators and modulators of motor, sensory, and autonomic functions in the intact CNS. This heterogeneous population of neurons is now widely appreciated to be a key component of plasticity and recovery. This review highlights our current understanding of spinal interneuron heterogeneity, their contribution to control and modulation of motor and sensory functions, and how this role might change after traumatic spinal cord injury. We also offer a perspective for how treatments can optimize the contribution of interneurons to functional improvement.

Original languageEnglish (US)
Pages (from-to)845-854
Number of pages10
JournalJournal of Neuroscience
Volume41
Issue number5
DOIs
StatePublished - Feb 3 2021
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • Interneuron
  • Plasticity
  • Propriospinal
  • Spinal cord

Fingerprint

Dive into the research topics of 'Spinal interneurons as gatekeepers to neuroplasticity after injury or disease'. Together they form a unique fingerprint.

Cite this