(Chemical Equetion Presentation) The synthesis of a C1-C19 precursor to pectenotoxin 4 is presented. The strategy employed the functionalized aliene shown. Key features include: olefin metathesis of two simple fragments to prepare the left portion of the allene-precursor, diastereoselective propargylation of an epoxy aldehyde to form the right portion, use of the DMDO-stable m-fluorobenzyl ether, and an aliene spirodiepoxidation/C-ring formation cascade.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Mar 5 2010|
All Science Journal Classification (ASJC) codes
- Physical and Theoretical Chemistry
- Organic Chemistry