Spontaneous fos expression in the suprachiasmatic nucleus of young and old mice

Jonathan P. Miller; J. Devin McAuley; Kevin C.H. Pang

doi:10.1016/j.neurobiolaging.2004.08.008

Spontaneous fos expression in the suprachiasmatic nucleus of young and old mice

Jonathan P. Miller, J. Devin McAuley, Kevin C.H. Pang

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The senescence-accelerated mouse (SAMP8) is an animal model of aging that displays an array of circadian rhythm disruptions as early as 7 months of age. The present study explored the physiological basis for age-related changes in circadian rhythms by measuring c-Fos immunostaining. Cellular activity in the SCN "core" and "shell" was examined for 2-, 7-, and 12-month-old SAMP8 at circadian times (CTs) 2 and 14. Consistent with previous studies in rats, we observed higher levels of cellular activity at CT2 than at CT14, and higher levels of activity in the "shell" than in the "core" of the SCN. However, there was no effect of age on the pattern of cellular activity in either the "core" or the "shell" of the SCN. These results are discussed in the context of current research on spontaneous and light-induced c-Fos expression in the SCN of rodents.

Original language	English (US)
Pages (from-to)	1107-1115
Number of pages	9
Journal	Neurobiology of Aging
Volume	26
Issue number	7
DOIs	https://doi.org/10.1016/j.neurobiolaging.2004.08.008
State	Published - Jul 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

Keywords

Aging
Circadian rhythm
SAMP8
SCN
Senescence-accelerated mouse
Suprachiasmatic nucleus
c-Fos

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10.1016/j.neurobiolaging.2004.08.008

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abstract = "The senescence-accelerated mouse (SAMP8) is an animal model of aging that displays an array of circadian rhythm disruptions as early as 7 months of age. The present study explored the physiological basis for age-related changes in circadian rhythms by measuring c-Fos immunostaining. Cellular activity in the SCN {"}core{"} and {"}shell{"} was examined for 2-, 7-, and 12-month-old SAMP8 at circadian times (CTs) 2 and 14. Consistent with previous studies in rats, we observed higher levels of cellular activity at CT2 than at CT14, and higher levels of activity in the {"}shell{"} than in the {"}core{"} of the SCN. However, there was no effect of age on the pattern of cellular activity in either the {"}core{"} or the {"}shell{"} of the SCN. These results are discussed in the context of current research on spontaneous and light-induced c-Fos expression in the SCN of rodents.",

keywords = "Aging, Circadian rhythm, SAMP8, SCN, Senescence-accelerated mouse, Suprachiasmatic nucleus, c-Fos",

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AU - Miller, Jonathan P.

AU - McAuley, J. Devin

AU - Pang, Kevin C.H.

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N2 - The senescence-accelerated mouse (SAMP8) is an animal model of aging that displays an array of circadian rhythm disruptions as early as 7 months of age. The present study explored the physiological basis for age-related changes in circadian rhythms by measuring c-Fos immunostaining. Cellular activity in the SCN "core" and "shell" was examined for 2-, 7-, and 12-month-old SAMP8 at circadian times (CTs) 2 and 14. Consistent with previous studies in rats, we observed higher levels of cellular activity at CT2 than at CT14, and higher levels of activity in the "shell" than in the "core" of the SCN. However, there was no effect of age on the pattern of cellular activity in either the "core" or the "shell" of the SCN. These results are discussed in the context of current research on spontaneous and light-induced c-Fos expression in the SCN of rodents.

AB - The senescence-accelerated mouse (SAMP8) is an animal model of aging that displays an array of circadian rhythm disruptions as early as 7 months of age. The present study explored the physiological basis for age-related changes in circadian rhythms by measuring c-Fos immunostaining. Cellular activity in the SCN "core" and "shell" was examined for 2-, 7-, and 12-month-old SAMP8 at circadian times (CTs) 2 and 14. Consistent with previous studies in rats, we observed higher levels of cellular activity at CT2 than at CT14, and higher levels of activity in the "shell" than in the "core" of the SCN. However, there was no effect of age on the pattern of cellular activity in either the "core" or the "shell" of the SCN. These results are discussed in the context of current research on spontaneous and light-induced c-Fos expression in the SCN of rodents.

KW - Aging

KW - Circadian rhythm

KW - SAMP8

KW - SCN

KW - Senescence-accelerated mouse

KW - Suprachiasmatic nucleus

KW - c-Fos

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Spontaneous fos expression in the suprachiasmatic nucleus of young and old mice

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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