Squamous cell carcinoma in dominant type epidermolysis bullosa dystrophica

Robert Allen Schwartz, Arthur P. Birnkrant, Daniel Jay Rubenstein, Untae Kim, Gordon H. Burgess, Howard L. Stoll, Soon W. Chai, Graeme J. Southwick, Halina Milgrom

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


The unusual genetic disorder epidermolysis bullosa dystrophica has been reported in several patients in whom the chronic cutaneous scars led to the development of cutaneous squamous cell carcinoma. However, only one of these previously reported cases involved the autosomal dominant form of the disease; the remainder occurred in its recessive counterpart. We report the second and third patients with squamous cell carcinoma associated with the dominant form of epidermolysis bullosa dystrophica. In addition, we not only observed the previous electron microscopic findings of decreased numbers of anchoring fibrils beneath the basal lamina but have also noted marked disruption of the basal lamina itself.

Original languageEnglish (US)
Pages (from-to)615-620
Number of pages6
Issue number3
StatePublished - Feb 1 1981

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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