Stability of DNA duplexes containing hypoxanthine (inosine): Gas versus solution phase and biological implications

Xuejun Sun, Jeehiun K. Lee

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

"Chemical Equation Presented" A series of 9-mer DNA duplexes of the sequence 5'-d(GGTTXTTGG)-373'-d(CCAAYAACC)-5', where the central base X or Y = adenine (A), guanine (G), thymine (T), cytosine (C), and hypoxanthine (H), have been examined toward, understanding the effect of hypoxanthine on DNA stability. Comparison of the duplex stability in the gas phase versus solution indicates that hypoxanthine has much less of a destabilizing effect in the gas phase versus in solution, relative to the normal complementary duplexes. The biological implications of these results, both in the context of hypoxanthine as a universal, base and as a damaged base, are discussed.

Original languageEnglish (US)
Pages (from-to)1848-1854
Number of pages7
JournalJournal of Organic Chemistry
Volume75
Issue number6
DOIs
StatePublished - Mar 19 2010

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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