TY - JOUR
T1 - Stability of DNA duplexes containing hypoxanthine (inosine)
T2 - Gas versus solution phase and biological implications
AU - Sun, Xuejun
AU - Lee, Jeehiun K.
PY - 2010/3/19
Y1 - 2010/3/19
N2 - "Chemical Equation Presented" A series of 9-mer DNA duplexes of the sequence 5'-d(GGTTXTTGG)-373'-d(CCAAYAACC)-5', where the central base X or Y = adenine (A), guanine (G), thymine (T), cytosine (C), and hypoxanthine (H), have been examined toward, understanding the effect of hypoxanthine on DNA stability. Comparison of the duplex stability in the gas phase versus solution indicates that hypoxanthine has much less of a destabilizing effect in the gas phase versus in solution, relative to the normal complementary duplexes. The biological implications of these results, both in the context of hypoxanthine as a universal, base and as a damaged base, are discussed.
AB - "Chemical Equation Presented" A series of 9-mer DNA duplexes of the sequence 5'-d(GGTTXTTGG)-373'-d(CCAAYAACC)-5', where the central base X or Y = adenine (A), guanine (G), thymine (T), cytosine (C), and hypoxanthine (H), have been examined toward, understanding the effect of hypoxanthine on DNA stability. Comparison of the duplex stability in the gas phase versus solution indicates that hypoxanthine has much less of a destabilizing effect in the gas phase versus in solution, relative to the normal complementary duplexes. The biological implications of these results, both in the context of hypoxanthine as a universal, base and as a damaged base, are discussed.
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U2 - 10.1021/jo9023683
DO - 10.1021/jo9023683
M3 - Article
C2 - 20184296
AN - SCOPUS:77949812773
SN - 0022-3263
VL - 75
SP - 1848
EP - 1854
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 6
ER -