Stabilization of cytochrome p450j messenger ribonucleic acid in the diabetic rat

Byung J. Song; Tamihide Matsunaga; James P. Hardwick; Sang S. Park; Richard L. Veech; Chung S. Yang; Harry V. Gelboin; Frank J. Gonzalez

doi:10.1210/mend-1-8-542

Stabilization of cytochrome p450j messenger ribonucleic acid in the diabetic rat

Byung J. Song
, Tamihide Matsunaga
, James P. Hardwick
, Sang S. Park
, Richard L. Veech
, Chung S. Yang
, Harry V. Gelboin
, Frank J. Gonzalez

Research output: Contribution to journal › Article › peer-review

217 Scopus citations

Abstract

Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed in hepatic, pulmonary, and renal tissues and its level is elevated in ethanol- and acetone-treated rats as well as in diabetic rats induced by either streptozotocin or alloxan. Although P450j protein is substantially elevated by all inducing regimens, only in diabetic rats is P450j mRNA increased 10-fold. Nuclear run-on transcription analysis showed that this mRNA increase is not due to transcriptional activation but is due to specific stabilization of the P450j mRNA.

Original language	English (US)
Pages (from-to)	542-547
Number of pages	6
Journal	Molecular Endocrinology
Volume	1
Issue number	8
DOIs	https://doi.org/10.1210/mend-1-8-542
State	Published - Aug 1987
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Biology
Endocrinology

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10.1210/mend-1-8-542

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title = "Stabilization of cytochrome p450j messenger ribonucleic acid in the diabetic rat",

abstract = "Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed in hepatic, pulmonary, and renal tissues and its level is elevated in ethanol- and acetone-treated rats as well as in diabetic rats induced by either streptozotocin or alloxan. Although P450j protein is substantially elevated by all inducing regimens, only in diabetic rats is P450j mRNA increased 10-fold. Nuclear run-on transcription analysis showed that this mRNA increase is not due to transcriptional activation but is due to specific stabilization of the P450j mRNA.",

author = "Song, \{Byung J.\} and Tamihide Matsunaga and Hardwick, \{James P.\} and Park, \{Sang S.\} and Veech, \{Richard L.\} and Yang, \{Chung S.\} and Gelboin, \{Harry V.\} and Gonzalez, \{Frank J.\}",

year = "1987",

month = aug,

doi = "10.1210/mend-1-8-542",

language = "English (US)",

volume = "1",

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journal = "Molecular Endocrinology",

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AU - Song, Byung J.

AU - Matsunaga, Tamihide

AU - Hardwick, James P.

AU - Park, Sang S.

AU - Veech, Richard L.

AU - Yang, Chung S.

AU - Gelboin, Harry V.

AU - Gonzalez, Frank J.

PY - 1987/8

Y1 - 1987/8

N2 - Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed in hepatic, pulmonary, and renal tissues and its level is elevated in ethanol- and acetone-treated rats as well as in diabetic rats induced by either streptozotocin or alloxan. Although P450j protein is substantially elevated by all inducing regimens, only in diabetic rats is P450j mRNA increased 10-fold. Nuclear run-on transcription analysis showed that this mRNA increase is not due to transcriptional activation but is due to specific stabilization of the P450j mRNA.

AB - Cytochrome P450j, an enzyme involved in nitrosamine metabolism, is expressed in hepatic, pulmonary, and renal tissues and its level is elevated in ethanol- and acetone-treated rats as well as in diabetic rats induced by either streptozotocin or alloxan. Although P450j protein is substantially elevated by all inducing regimens, only in diabetic rats is P450j mRNA increased 10-fold. Nuclear run-on transcription analysis showed that this mRNA increase is not due to transcriptional activation but is due to specific stabilization of the P450j mRNA.

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UR - https://www.scopus.com/pages/publications/0023386817#tab=citedBy

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SP - 542

EP - 547

JO - Molecular Endocrinology

JF - Molecular Endocrinology

IS - 8

ER -

Stabilization of cytochrome p450j messenger ribonucleic acid in the diabetic rat

Abstract

All Science Journal Classification (ASJC) codes

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