Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology