Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action

Jin Xu, Ming Xu, Taylor Brown, Grace C. Rossi, Yasmin L. Hurd, Charles E. Inturrisi, Gavril W. Pasternak, Ying Xian Pan

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background: The μ-opioid receptor gene undergoes extensive alternative splicing. Results: The single transmembrane (TM) splice variants function as a chaperone to stabilize 7-TM MOR-1, enhancing morphine analgesia. Conclusion: Single TM variants play an important role in expression and function of 7-TM MOR-1. Significance: The function of truncated variants is significant for understanding the regulation ofμ-opioid receptors or other GPCR families.

Original languageEnglish (US)
Pages (from-to)21211-21227
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number29
DOIs
StatePublished - Jul 19 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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