Staphylococcal protein A adsorption in neoplastic disease: analysis of physicochemical aspects.

R. M. Murphy, C. K. Colton, M. L. Yarmush

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Staphylococcus aureus organisms and immobilized Staphylococcal protein A have been used as extracorporeal immunoadsorbents for the treatment of neoplastic disease. In a significant number of cases, a biologic response has been documented. This review analyzes the experimental results to date, correlates experimental design parameters with response to treatment, and discusses possible mechanisms of action. The evidence implicates protein A as the tumoricidal agent, although bacterial or complement components may act independently or synergistically. A more quantitative and fundamental approach is needed to exploit the potential for protein A immunoadsorption in treating neoplastic disease.

Original languageEnglish (US)
Pages (from-to)186-207
Number of pages22
JournalMolecular biotherapy
Volume1
Issue number4
StatePublished - 1989

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