Steady or changing? Long-term monitoring of neuronal population activity

Henry Lütcke, David J. Margolis, Fritjof Helmchen

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Stability and flexibility are both hallmarks of brain function that allow animals to thrive in ever-changing environments. Investigating how a balance between these opposing features is achieved with a dynamic array of cellular and molecular constituents requires long-term tracking of activity from individual neurons. Here, we review in vivo chronic extracellular recording studies and recent long-term two-photon calcium-imaging investigations that address the question of stability and plasticity of neuronal population activity in the mammalian brain. Overall, spiking activity is heterogeneously distributed among neurons in local populations and largely remains stable for individual cells over time. Tuning properties appear more flexible and may be adaptively stabilized, possibly by neuromodulators, to encode reliably and specifically salient stimuli or behaviors.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
JournalTrends in Neurosciences
Volume36
Issue number7
DOIs
StatePublished - Jul 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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