Stereocontrolled synthesis of diamines from iodolactams

Spencer Knapp, Anthony T. Levorse

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Displacement of iodide from iodolactams by azide occurs with retention of configuration if a catalytic amount of NaH is added, due to the intervention of an N-acyl-aziridine. Several diamine equivalents and a spermidine analogue are prepared in this way.

Original languageEnglish (US)
Pages (from-to)3213-3216
Number of pages4
JournalTetrahedron Letters
Issue number28
StatePublished - 1987

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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