Stereospecific synthesis of phosphatidylglycerol using a cyanoethyl phosphoramidite precursor

Zachary J. Struzik, Ashley N. Weerts, Judith Storch, David H. Thompson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Phosphatidylglycerols (PG) are a family of naturally occurring phospholipids that are responsible for critical operations within cells. PG are characterized by an (R) configuration in the diacyl glycerol backbone and an (S) configuration in the phosphoglycerol head group. Herein, we report a synthetic route to provide control over the PG stereocenters as well as control of the acyl chain identity.

Original languageEnglish (US)
Article number104933
JournalChemistry and Physics of Lipids
Volume231
DOIs
StatePublished - Sep 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

Keywords

  • Dioleoyl glycerophospholipid
  • Phosphatidylglycerol
  • Phosphoramidite methodology
  • Stereospecific synthesis

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