Steroid/nuclear receptor coactivators

Research output: Chapter in Book/Report/Conference proceedingChapter

45 Scopus citations

Abstract

In higher eukaryotes, steroids/thyroid hormones and many lipophilic compounds regulate cellular physiology through binding to the steroid/nuclear receptor proteins. Steroid/nuclear receptors are ligand-dependent transcriptional activators that can stimulate gene expression. This transcriptional activatons plays a pivotal role in hormone-regulated physiological and pharmacological responses. In recent years, several steroid/nuclear receptor cofactors have been identified and found to interact with the receptor and modulate its transcriptional activity. Among these cofactors, a family of three coactivators has been the focus of intense studies. Although gaps remain, progress has been made in understanding how a given coactivator interacts with the receptor and promotes transcriptional activation. We are beginning to understand coactivator action; for instance, several studies have established the molecular basis of antagonism by anti-hormones and the connection of coactivators with human cancers.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Pages391-448
Number of pages58
ISBN (Print)0127098585, 9780127098586
DOIs
StatePublished - 2000
Externally publishedYes

Publication series

NameVitamins and Hormones
Volume58
ISSN (Print)0083-6729

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology

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