Stigma variations: Observations on suppressor T cells and leprosy

Barry R. Bloom, Robert L. Modlin, Padmini Salgame

Research output: Contribution to journalReview articlepeer-review

126 Scopus citations

Abstract

Few areas of immunology have been so controversial as that of suppressor T cells. Studies of T cell clones derived from patients with infectious diseases, including leprosy, and allergies have allowed the delineation of functional human T cell subsets. Both CD4 and CD8 cells can be discriminated into subsets that are differentiated by their functions and patterns of lymphokines. Type I CD4 cells reactive with lepromin and PPD produce IFN-γ and IL-2 predominantly, while Type 2 CD4 clones, specific for tetanus toxoid, produce IL-4 and IL-5. Type 1 CD8 cytotoxic T lymphocytes produce predominantly IFN-γ and IL-2. T suppressor clones derived from immunologically unresponsive lepromatous leprosy patients are antigen-specific, CD8 cells, HLA-DQ restricted, and produce predominantly IL-4, and were designated Type 2 CD8 cells. Several models for peripheral tolerance based on distinct functional T cell subsets are discussed. Previous models of T cell suppression in the mouse and the reciprocal relationship between humoral and cell-mediated immunity in general are reinterpreted in light of such T cell subset interactions.

Original languageEnglish (US)
Pages (from-to)453-488
Number of pages36
JournalAnnual Review of Immunology
Volume10
StatePublished - Jun 5 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Keywords

  • HLA-DQ
  • human T-cell subsets
  • immunology of infectious diseases
  • lymphokines
  • tolerance

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