Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

András Spät; János G. Pitter; Tibor Rohács; György Szabadkai

doi:10.1152/physiologyonline.2001.16.5.197

Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

András Spät, János G. Pitter, Tibor Rohács, György Szabadkai

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Ca²⁺ signal in high-Ca²⁺ perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca²⁺-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca²⁺ signals may also augment mitochondrial Ca²⁺ concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.

Original language	English (US)
Pages (from-to)	197-200
Number of pages	4
Journal	News in Physiological Sciences
Volume	16
Issue number	5
DOIs	https://doi.org/10.1152/physiologyonline.2001.16.5.197
State	Published - Oct 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Physiology

Access to Document

10.1152/physiologyonline.2001.16.5.197

Cite this

@article{fa699e99ffb942b784ca45b490f6b389,

title = "Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells",

abstract = "Ca2+ signal in high-Ca2+ perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca2+-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca2+ signals may also augment mitochondrial Ca2+ concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.",

author = "Andr{\'a}s Sp{\"a}t and Pitter, {J{\'a}nos G.} and Tibor Roh{\'a}cs and Gy{\"o}rgy Szabadkai",

year = "2001",

month = oct,

doi = "10.1152/physiologyonline.2001.16.5.197",

language = "English (US)",

volume = "16",

pages = "197--200",

journal = "News in Physiological Sciences",

issn = "0886-1714",

publisher = "American Physiological Society",

number = "5",

}

TY - JOUR

T1 - Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

AU - Spät, András

AU - Pitter, János G.

AU - Rohács, Tibor

AU - Szabadkai, György

PY - 2001/10

Y1 - 2001/10

N2 - Ca2+ signal in high-Ca2+ perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca2+-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca2+ signals may also augment mitochondrial Ca2+ concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.

AB - Ca2+ signal in high-Ca2+ perimitochondrial microdomains is amplified within the mitochondrial matrix and activates Ca2+-dependent dehydrogenases. In steroid-secreting cells, small cytoplasmic Ca2+ signals may also augment mitochondrial Ca2+ concentration. The ensuing formation of NADH and NADPH may have an essential role in supporting the increased steroid secretion.

UR - http://www.scopus.com/inward/record.url?scp=0035490879&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035490879&partnerID=8YFLogxK

U2 - 10.1152/physiologyonline.2001.16.5.197

DO - 10.1152/physiologyonline.2001.16.5.197

M3 - Article

C2 - 11572920

AN - SCOPUS:0035490879

SN - 0886-1714

VL - 16

SP - 197

EP - 200

JO - News in Physiological Sciences

JF - News in Physiological Sciences

IS - 5

ER -

Stimulus-secretion coupling and mitochondrial metabolism in steroid-secreting cells

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this