Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy

Prashanth Sreeramoju, Steven K. Libutti

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Effective cancer therapy remains a challenge despite recent advances in the identification of novel targets. A major limitation of most chemotherapeutic drugs is their systemic toxicity and the efficacy of cancer treatments is, by and large, determined by the ability to balance their benefits against their toxicity. Targeted treatments for cancer, especially those that target the tumor vasculature, have provided promising antitumor results with minimal systemic toxicity. To date significant progress has been made in developing a variety of delivery systems to target cancer and its vasculature ranging from isolated limb and organ perfusion to tumor targeted biological and nonbiological vectors.

Original languageEnglish (US)
Pages (from-to)135-152
Number of pages18
JournalAdvances in Genetics
Volume69
Issue numberC
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics

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