Stress-induced alteration of polymorphonuclear leukocyte function in rats

Michael R. Shurin, Alex Kusnecov, Ellen Hamill, Sandra Kaplan, Bruce S. Rabin

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

We have used a laboratory model of footshock stress in rats to determine whether stressor-induced alterations can be induced in polymorphonuclear leukocyte (PMN) function. We studied the ability of peripheral blood PMN to ingest and kill gram-positive bacteria. A single, 1-h session of footshock stress did not alter the ability of PMN to ingest or kill bacteria. However, 3 consecutive days of a 1-h session of footshock stress significantly enhanced the phagocytic activity of PMN but suppressed the ability of PMN to kill bacteria. Thus, this experimental model suggests that both the phagocytic and killing functions of PMN can be altered by repeated exposure to a stressor.

Original languageEnglish (US)
Pages (from-to)163-169
Number of pages7
JournalBrain, Behavior, and Immunity
Volume8
Issue number2
DOIs
StatePublished - Jun 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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