Stretch‐activation of rat cardiac myocytes

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Abstract

Mechanically activated ion channels (MACs) in rat ventricular myocytes were activated by stretching membrane patches attached to microelectrodes. Charge injection from MACs, consisting mainly of inward K+, was sometimes of sufficient magnitude (0.2 pC) during brief (50 ms) periods, to trigger action currents. Action currents were shown to be extracellular records of action potentials. These results demonstrate the activation of myocytes by injection of approximately 4 pA from a few MACs in a membrane patch.

Original languageEnglish (US)
Pages (from-to)411-423
Number of pages13
JournalExperimental Physiology
Volume78
Issue number3
DOIs
StatePublished - May 1 1993

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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