Structural and antitrypanosomal data of different carbasones of piperitone

Amoussatou Sakirigui, Fernand Gbaguidi, Urbain C. Kasséhin, Jacques Poupaert, Georges C. Accrombessi, Simeon O. Kotchoni

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Abstract

This article reports data on four carbazones of piperitone: semicarbazone 1, thiosemicarbazone 2, 4-phenyl semicarbazone 3 and 4-phenyl thiosemicarbazone 4 prepared directly in situ from essential oil of Cymbopogon schoenantus, whose GC-FID and GC–MS analysis revealed piperitone as major component (68.20%). The structures of hemi-synthesized compounds were confirmed by high throughput IR, MS, 1H and 13C NMR based spectrometric analysis. Their antiparasitic activities were evaluated in vitro on Trypanosoma brucei brucei (Tbb). The compound 3 (IC50=8.63±0.81 µM) and 4 (IC50=10.90±2.52 µM) exhibited antitrypanosomal activity, 2 had a moderate activity (IC50=74.58±4.44 µM) but 1 was void of significant activity (IC50=478.47 µM). The in vitro tests showed that all compounds were less cytotoxic against the human non cancer fibroblast cell line (WI38) (IC50>80 µM) while only 2 (IC50=21.16±1.37 μM) and 4 (IC50=32.22±1.66 µM) were cytotoxic against the Chinese Hamster Ovary (CHO) cells and toxic on Artemia salina (Leach) larvae. Piperitone 4-phenyl semicarbazone 3, the best antitrypanosomal compound, showed also a selectivity index (SI) higher than 7 on the larvae and the tested cells and therefore might be further studied as antitrypanosomal agent. Also, all compounds except 3 showed selectivity between the two tested cell lines (SI>2). This data reveals for the first time the antitrypinosomal properties of thiosemicarbazones, their cytotoxicity on mammalian cells as well as their activities against Tbb and A. salina Leach.

Original languageEnglish (US)
Pages (from-to)1039-1043
Number of pages5
JournalData in Brief
Volume9
DOIs
Publication statusPublished - Dec 2016

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All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Artemia salina
  • Cymbopogon shoenantus
  • Essential oil
  • Hemi-synthesized
  • Piperitone carbazones
  • Trypanosoma brucei brucei

Cite this

Sakirigui, A., Gbaguidi, F., Kasséhin, U. C., Poupaert, J., Accrombessi, G. C., & Kotchoni, S. O. (2016). Structural and antitrypanosomal data of different carbasones of piperitone. Data in Brief, 9, 1039-1043. https://doi.org/10.1016/j.dib.2016.11.044