Structural characterization of neutral oligosaccharides of human H+Leb+ gastric mucin

B. L. Slomiany, E. Zdebska, A. Slomiany

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The structure of carbohydrate chains of human gastric mucin was investigated. The mucin, purified from pronase-degraded gastric aspirates of the secretors with blood group H+Leb, was subjected to alkaline borohydride treatment and a heterogeneous population of neutral (72.1%) and acidic (27.9%) oligosaccharide alditols was obtained. Ten oligosaccharides, representing 80.3% of the neutral oligosaccharide fraction, have been purified to homogeneity and their structures determined. These oligosaccharides ranged in length from 4 to 12 sugar units and contained mono-, bi-, and triantennary structures. Based on hemagglutination inhibition data in H-anti-H, Leb-anti-Leb, and I-anti-I systems, and the results of structural analyses, the authors present the structures for these oligosaccharides.

Original languageEnglish (US)
Pages (from-to)2863-2869
Number of pages7
JournalJournal of Biological Chemistry
Issue number5
StatePublished - 1984
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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