Structural DNA nanotechnology: State of the art and future perspective

Fei Zhang, Jeanette Nangreave, Yan Liu, Hao Yan

Research output: Contribution to journalReview articlepeer-review

472 Scopus citations


Over the past three decades DNA has emerged as an exceptional molecular building block for nanoconstruction due to its predictable conformation and programmable intra- and intermolecular Watson-Crick base-pairing interactions. A variety of convenient design rules and reliable assembly methods have been developed to engineer DNA nanostructures of increasing complexity. The ability to create designer DNA architectures with accurate spatial control has allowed researchers to explore novel applications in many directions, such as directed material assembly, structural biology, biocatalysis, DNA computing, nanorobotics, disease diagnosis, and drug delivery. This Perspective discusses the state of the art in the field of structural DNA nanotechnology and presents some of the challenges and opportunities that exist in DNA-based molecular design and programming.

Original languageEnglish (US)
Pages (from-to)11198-11211
Number of pages14
JournalJournal of the American Chemical Society
Issue number32
StatePublished - Aug 13 2014
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


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