Structural genomics of protein phosphatases

Steven C. Almo, Jeffrey B. Bonanno, J. Michael Sauder, Spencer Emtage, Teresa P. Dilorenzo, Vladimir Malashkevich, Steven R. Wasserman, S. Swaminathan, Subramaniam Eswaramoorthy, Rakhi Agarwal, Desigan Kumaran, Mahendra Madegowda, Sugadev Ragumani, Yury Patskovsky, Johnjeff Alvarado, Udupi A. Ramagopal, Joana Faber-Barata, Mark R. Chance, Andrej Sali, Andras FiserZhong Yin Zhang, David S. Lawrence, Stephen K. Burley

Research output: Contribution to journalReview articlepeer-review

125 Scopus citations


The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

Original languageEnglish (US)
Pages (from-to)121-140
Number of pages20
JournalJournal of Structural and Functional Genomics
Issue number2-3
StatePublished - Sep 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Genetics


  • Phosphatase
  • Structural genomics
  • X-ray crystallography


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