Structure-activity analyses of HIV-1 reverse transcriptase

Amaresh Basu, Subhalakshmi Basu, Mukund Modak

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

HIV-1 reverse transcriptase is a dimeric enzyme which can exist in both homodimeric (p66/p66) and heterodimeric (p66/p51) forms. The monomeric subunits are catalytically inert. However, during DNA synthesis by the dimeric enzyme, only one subunit (p66) appears to carry out the catalysis, while the second subunit serves only a supportive role. In the case of the p66/p66 homodimers, we find that both the subunits are catalytically competent as judged by the observation that a) primer binding occurs to both subunits and b) catalytically inert dimers can be partially activated by replacement of one of the two inactive p66 subunits.

Original languageEnglish (US)
Pages (from-to)1131-1138
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume183
Issue number3
DOIs
StatePublished - Mar 31 1992

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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