Structure-activity relationship studies on quorum sensing ComXRO-E-2 pheromone

Masahiro Okada, Hisao Yamaguchi, Isao Sato, Soo Jeong Cho, David Dubnau, Youji Sakagami

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Abstract

The ComX pheromone is a posttranslationally modified oligopeptide that stimulates natural genetic competence in Bacillus subtilis. Various ComXRO-E-2 analogs were synthesized and their biological activities were studied to investigate structure-activity relationships. These results showed that the minimal active unit was the tripeptide, [3-5]ComXRO-E-2, and all residues except the modified tryptophan residue were replaceable by alanine without total loss of activity.

Original languageEnglish (US)
Pages (from-to)1705-1707
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number6
DOIs
StatePublished - Mar 15 2007

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Keywords

  • Bacillus subtilis
  • ComX
  • Posttranslational modification
  • Quorum sensing
  • Structure-activity relationship

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