Structure-activity relationship studies on quorum sensing ComXRO-E-2 pheromone

Masahiro Okada, Hisao Yamaguchi, Isao Sato, Soo Jeong Cho, David Dubnau, Youji Sakagami

Research output: Contribution to journalArticle

16 Scopus citations


The ComX pheromone is a posttranslationally modified oligopeptide that stimulates natural genetic competence in Bacillus subtilis. Various ComXRO-E-2 analogs were synthesized and their biological activities were studied to investigate structure-activity relationships. These results showed that the minimal active unit was the tripeptide, [3-5]ComXRO-E-2, and all residues except the modified tryptophan residue were replaceable by alanine without total loss of activity.

Original languageEnglish (US)
Pages (from-to)1705-1707
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
StatePublished - Mar 15 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


  • Bacillus subtilis
  • ComX
  • Posttranslational modification
  • Quorum sensing
  • Structure-activity relationship

Fingerprint Dive into the research topics of 'Structure-activity relationship studies on quorum sensing ComX<sub>RO-E-2</sub> pheromone'. Together they form a unique fingerprint.

Cite this