@article{eccaa935ac084bb095765b526620c027,
title = "Structure and function of the ventricular tachycardia isthmus",
abstract = "Catheter ablation of postinfarction reentrant ventricular tachycardia (VT) has received renewed interest owing to the increased availability of high-resolution electroanatomic mapping systems that can describe the VT circuits in greater detail, and the emergence and need to target noninvasive external beam radioablation. These recent advancements provide optimism for improving the clinical outcome of VT ablation in patients with postinfarction and potentially other scar-related VTs. The combination of analyses gleaned from studies in swine and canine models of postinfarction reentrant VT, and in human studies, suggests the existence of common electroanatomic properties for reentrant VT circuits. Characterizing these properties may be useful for increasing the specificity of substrate mapping techniques and for noninvasive identification to guide ablation. Herein, we describe properties of reentrant VT circuits that may assist in elucidating the mechanisms of onset and maintenance, as well as a means to localize and delineate optimal catheter ablation targets.",
keywords = "Catheter ablation, Isthmus, Mapping, Reentrant circuit, Ventricular tachycardia",
author = "Ciaccio, {Edward J.} and Elad Anter and James Coromilas and Wan, {Elaine Y.} and Hirad Yarmohammadi and Wit, {Andrew L.} and Peters, {Nicholas S.} and Hasan Garan",
note = "Funding Information: Funding Sources: Dr Peters acknowledges funding for data analysis from the British Heart Foundation (RG/16/3/32175 and Centre of Research Excellence), Rosetrees Trust, and the National Institute for Health Research (UK) Biomedical Research Centre. Dr Wan acknowledges funding for data analysis from the National Institutes of Health, R01HL152236. Disclosures: Dr Anter has received research grants and consultation fees from Biosense Webster, Inc. He also receives research grants and consultation fees from Affera Inc, Boston Scientific, Itamar Medical, and Phillips Health. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Funding Information: Funding sources: Dr Peters acknowledges funding for data analysis from the British Heart Foundation (RG/16/3/32175 and Centre of Research Excellence), Rosetrees Trust, and the National Institute for Health Research (UK) Biomedical Research Centre. Dr Wan acknowledges funding for data analysis from the National Institutes of Health, R01HL152236. Disclosures: Dr Anter has received research grants and consultation fees from Biosense Webster, Inc. He also receives research grants and consultation fees from Affera Inc, Boston Scientific, Itamar Medical, and Phillips Health. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2021 Heart Rhythm Society",
year = "2022",
month = jan,
doi = "10.1016/j.hrthm.2021.08.001",
language = "English (US)",
volume = "19",
pages = "137--153",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "1",
}