Structure, function and expression of voltage-dependent sodium channels

Roland G. Kallen, Sidney A. Cohen, Robert L. Barchi

Research output: Contribution to journalArticlepeer-review

73 Scopus citations


Voltage-dependent sodium channels control the transient inward current responsible for the action potential in most excitable cells. Members of this multigene family have been cloned, sequenced, and functionally expressed from various tissues and species, and common features of their structure have clearly emerged. Site-directed mutagenesis coupled with in vitro expression has provided additional insight into the relationship between structure and function. Subtle differences between sodium channel isoforms are also important, and aspects of the regulation of sodium channel gene expression and the modulation of channel function are becoming topics of increasing importance. Finally, sodium channel mutations have been directly linked to human disease, yielding insight into both disease pathophysiology and normal channel function. After a brief discussion of previous work, this review will focus on recent advances in each of these areas.

Original languageEnglish (US)
Pages (from-to)383-428
Number of pages46
JournalMolecular Neurobiology
Issue number3-4
StatePublished - Sep 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cellular and Molecular Neuroscience


  • Voltage-dependent ion channel
  • site-directed mutagenesis
  • sodium channel diseases


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