Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes

Keyphrases

• Activity Profile 50%
• Binding Pocket 50%
• Binding Region 50%
• Catalytic Complexes 50%
• Chemical Cross-linking 50%
• Chemical Modification 50%
• Conformational Change 100%
• Cross-linked 50%
• Disulfide 50%
• DNA Interstrand Crosslinks 100%
• DNA Polymerase 50%
• DNA Structures 50%
• Duplex 50%
• HIV Infection 50%
• HIV-1 Reverse Transcriptase 100%
• HIV-1 RT 50%
• Lipodystrophy 50%
• Neuropathy 50%
• Nucleoside Analogues 100%
• Overhang 50%
• PH Dependence 100%
• RNA-dependent RNA Polymerase (RdRP) 50%
• Single-stranded DNA (ssDNA) 100%
• Stavudine 50%
• Template-primer 50%
• Thumb 50%
• Triphosphate 50%
• X-ray Structure 50%

Biochemistry, Genetics and Molecular Biology

• Adenine 20%
• Conformational Change 100%
• Cross-Link 80%
• Crosslinking of DNA 100%
• Disulfide 20%
• DNA Polymerase 20%
• DNA Template 20%
• Human Immunodeficiency Virus 20%
• Human Immunodeficiency Virus 1 20%
• Motion 40%
• Nucleoside Analog 40%
• Reverse Transcriptase 100%
• RNA Polymerase 20%
• Stavudine 100%
• X Ray 20%