@article{6e64fb070f7f4598a798aebd183131a2,
title = "Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference",
abstract = "Structures of the type III-A CRISPR-Csm complex in the presence of target RNAs reveal the molecular basis for a unique mode of self/non-self discrimination.",
keywords = "CRISPR-Cas 9 system, Csm complex, type III-A",
author = "Lilan You and Jun Ma and Jiuyu Wang and Daria Artamonova and Min Wang and Liang Liu and Hua Xiang and Konstantin Severinov and Xinzheng Zhang and Yanli Wang",
note = "Funding Information: We thank the staff of the BL-17U1 and BL-19U1 beamlines at Shanghai Synchrotron Radiation Facility. We thank B. Zhu, X. Huang, G. Ji, D. Fan, F. Sun, and the other staff at the Center for Biological Imaging (IBP, CAS) for their support in cryo-EM data collection. We thank Matvey Kolesnik for assistance with RNA-seq data analysis and Hongjie Zhang at IBP for the guidance in handling radiolabeled chemicals. We thank Dr. Torsten Juelich (Peking University, China) for critical reading of the manuscript and linguistic assistance and Prof. Ruiming Xu for scientific discussion. This work was supported by the Chinese Ministry of Science and Technology ( 2017YFA0504203 and 2017YFA0504700 ), the Natural Science Foundation of China ( 31630015 , 91440201 , 31571335 , 31700662 , and 31400640 ), the Strategic Priority Research Program of the Chinese Academy of Sciences ( XDB08010203 and XDB08030204 ), and the Opening Project of the State Key Laboratory of Microbial Resources . X.Z. received scholarships from the National Thousand (Young) Talents Program from the Office of Global Experts Recruitment in China . Work in K.S. laboratory is supported by NIH ( R01 GM10407 ) and Russian Science Foundation ( 14-14-00988 ). D.A. was supported by Foundation for Assistance to Small Innovative Enterprises program “UMNIK” under the contract N 9188GU/2015 (0019877) of 12/24/2015. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "10",
doi = "10.1016/j.cell.2018.10.052",
language = "English (US)",
volume = "176",
pages = "239--253.e16",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1-2",
}