Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

Lilan You, Jun Ma, Jiuyu Wang, Daria Artamonova, Min Wang, Liang Liu, Hua Xiang, Konstantin Severinov, Xinzheng Zhang, Yanli Wang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Structures of the type III-A CRISPR-Csm complex in the presence of target RNAs reveal the molecular basis for a unique mode of self/non-self discrimination.

Original languageEnglish (US)
Pages (from-to)239-253.e16
JournalCell
Volume176
Issue number1-2
DOIs
StatePublished - Jan 10 2019

Fingerprint

Clustered Regularly Interspaced Short Palindromic Repeats
RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • CRISPR-Cas 9 system
  • Csm complex
  • type III-A

Cite this

You, L., Ma, J., Wang, J., Artamonova, D., Wang, M., Liu, L., ... Wang, Y. (2019). Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. Cell, 176(1-2), 239-253.e16. https://doi.org/10.1016/j.cell.2018.10.052
You, Lilan ; Ma, Jun ; Wang, Jiuyu ; Artamonova, Daria ; Wang, Min ; Liu, Liang ; Xiang, Hua ; Severinov, Konstantin ; Zhang, Xinzheng ; Wang, Yanli. / Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. In: Cell. 2019 ; Vol. 176, No. 1-2. pp. 239-253.e16.
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You, L, Ma, J, Wang, J, Artamonova, D, Wang, M, Liu, L, Xiang, H, Severinov, K, Zhang, X & Wang, Y 2019, 'Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference', Cell, vol. 176, no. 1-2, pp. 239-253.e16. https://doi.org/10.1016/j.cell.2018.10.052

Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. / You, Lilan; Ma, Jun; Wang, Jiuyu; Artamonova, Daria; Wang, Min; Liu, Liang; Xiang, Hua; Severinov, Konstantin; Zhang, Xinzheng; Wang, Yanli.

In: Cell, Vol. 176, No. 1-2, 10.01.2019, p. 239-253.e16.

Research output: Contribution to journalArticle

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AU - Ma, Jun

AU - Wang, Jiuyu

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AU - Wang, Min

AU - Liu, Liang

AU - Xiang, Hua

AU - Severinov, Konstantin

AU - Zhang, Xinzheng

AU - Wang, Yanli

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You L, Ma J, Wang J, Artamonova D, Wang M, Liu L et al. Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. Cell. 2019 Jan 10;176(1-2):239-253.e16. https://doi.org/10.1016/j.cell.2018.10.052