Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

Lilan You, Jun Ma, Jiuyu Wang, Daria Artamonova, Min Wang, Liang Liu, Hua Xiang, Konstantin Severinov, Xinzheng Zhang, Yanli Wang

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Structures of the type III-A CRISPR-Csm complex in the presence of target RNAs reveal the molecular basis for a unique mode of self/non-self discrimination.

Original languageEnglish (US)
Pages (from-to)239-253.e16
JournalCell
Volume176
Issue number1-2
DOIs
StatePublished - Jan 10 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • CRISPR-Cas 9 system
  • Csm complex
  • type III-A

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  • Cite this

    You, L., Ma, J., Wang, J., Artamonova, D., Wang, M., Liu, L., Xiang, H., Severinov, K., Zhang, X., & Wang, Y. (2019). Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference. Cell, 176(1-2), 239-253.e16. https://doi.org/10.1016/j.cell.2018.10.052