Structures of bacterial immunoglobulin-binding domains and their complexes with immunoglobulins

Mitsuru Tashiro, Gaetano T. Montelione

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

Three-dimensional structures are now available for several immunoglobulin binding domains from bacterial proteins A, G, and L. X-ray diffraction and NMR experiments on complexes of these domains with portions of immunoglobulins have revealed common structural themes used in these interactions. These data expand our understanding of structure/function relationships in these molecular recognition processes and provide the basis for rational design of artificial immunoglobulin-binding molecules.

Original languageEnglish (US)
Pages (from-to)471-481
Number of pages11
JournalCurrent Opinion in Structural Biology
Volume5
Issue number4
DOIs
StatePublished - Aug 1995

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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