Strychnine antagonizes vaginal stimulation-produced analgesia at the spinal cord

Lowell A. Roberts, Carlos Beyer, Barry R. Komisaruk

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Vaginal-cervical mechanostimulation (VS) suppresses vocalization and withdrawal responses to noxious stimulation. To determine whether the inhibitory neurotransmitter, glycine, contributes to the action of VS, strychnine, a specific glycine receptor antagonist was administered perispinally via intrathecal catheter in dosages of 1,5,25 and 100 μg. Prior to strychnine administration, VS (400 g force) elevated thresholds to elicit vocalization in response to graded intensities of tail shock, and blocked vocalization elicited by stimulation of a skin area, previously sensitized by intradermal injection of a 20% yeast solution. After strychnine administration the analgesic effects of VS were significantly attenuated. These findings suggest that the analgesic action of VS is partially mediated by glycine at the spinal level.

Original languageEnglish (US)
Pages (from-to)2017-2023
Number of pages7
JournalLife Sciences
Volume36
Issue number21
DOIs
StatePublished - May 27 1985

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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