Studies of Campylobacter jejuni in patients with inflammatory bowel disease

Martin J. Blaser, David Hoverson, Ilene G. Ely, Deborah J. Duncan, Wen Lan L. Wang, William R. Brown

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Cultures, serology, and immunohistochemical tests for Campylobacter jejuni were performed on 74 patients with inflammatory bowel disease of various disease activity and in healthy and diseased control populations. Fecal cultures were negative in all groups tested. Antibodies to C. Jejuni were assessed both by a complement fixation assay and an enzyme-linked immunosorbent assay to multiple serotypes of the organism. Antibody titers in inflammatory bowel disease patients and control populations were similar, and titers in these groups were significantly lower than in patients with acute Campylobacter enteritis. Intestinal tissues examined for Campylobacter antigens by an indirect fluorescent antibody assay were negative. These data do not etiologically implicate C. jejuni in Crohn's disease or chronic ulcerative colitis.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalGastroenterology
Volume86
Issue number1
DOIs
StatePublished - Jan 1984

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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