Studies of particle packings in mixtures of pharmaceutical excipients

M. Dutt, B. Hancock, C. Bentham, J. Elliott

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pharmaceutical powder blends used togenerate tablets are complex multicomponent mixtures of the drug powder and excipients which facilitate the delivery of the required drug. The individual constituents of these blends can be noncohesive and cohesive powders. We study the geometric and mechanical characteristics of idealized mixtures of excipient particle packings, for a small but representative number of dry noncohesive particles, generated via gravitational compaction followed by uniaxial compaction. We discuss particle packings in 2- and 3-component mixtures of microcrystalline cellulose (MCC) & lactose and MCC, starch & lactose, respectively. We have computed the evolution of the force and stress distributions in monodisperse and polydisperse mixtures comprised of equal parts of each excipient; comparisons are made with results for particles packings of pure blends of MCC and lactose. We also compute the stress-strain relations for these mixtures. In order to obtain insight into details of the particle packings, we calculate the coordination number, packing fraction, radial distribution functions and contact angle distributions for the various mixtures. The numerical experiments have been performed on spheroidal idealizations of the excipient grains using Discrete Element Method simulations (Dutt et al., 2004 submitted).

Original languageEnglish (US)
Title of host publicationPowders and Grains 2005 - Proceedings of the 5th International Conference on Micromechanics of Granular Media
Pages17-20
Number of pages4
StatePublished - 2005
Externally publishedYes
Event5th International Conference on the Micromechanics of Granular Media: Powders and Grains 2005 - Stuttgart, Germany
Duration: Jul 18 2005Jul 22 2005

Publication series

NamePowders and Grains 2005 - Proceedings of the 5th International Conference on Micromechanics of Granular Media
Volume1

Other

Other5th International Conference on the Micromechanics of Granular Media: Powders and Grains 2005
CountryGermany
CityStuttgart
Period7/18/057/22/05

All Science Journal Classification (ASJC) codes

  • Materials Science (miscellaneous)

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