Studies on the deamination of the ethyl ester of 5-amino-3-methylisoxazole- 4-carboxylic Acid

S. Ryng, M. Szostak

Research output: Contribution to journalArticle

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Abstract

The unusual behavior of the ethyl ester of 5-amino-3-methylisoxazole-4- carboxylic acid (1) during deamination is described. Possible explanations for the anomalies of the diazotization reaction are proposed. Deamination methods leading to ethyl ester of 3-methylisoxazole-4-carboxylic acid (5) are presented. 5 will serve as a lead compound for a new series of immunomodulatory agents.

Original languageEnglish (US)
Pages (from-to)887-893
Number of pages7
JournalPolish Journal of Chemistry
Volume83
Issue number5
Publication statusPublished - May 1 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Keywords

  • Deamination
  • Diazotization
  • Hydrogen bonding
  • Immunological activity
  • Isoxazoles

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