Studies on the role of bacteriophage T7 lysozyme during phage infection

Samuel Silberstein, Masayori Inouye, F. William Studier

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Bacteriophage T7 lysozyme is not required for lysis of the host but instead is involved in DNA metabolism after infection. The lysozyme apparently causes release of host DNA from its membrane complex, but this release is not needed for efficient degradation of host DNA. Therefore, the effects of lysozyme deficiency on DNA synthesis cannot be explained as a reduction in the availability of precursors. T7 lysozyme also causes release of newly made T7 DNA (or phage particles) from the membrane and this may be its primary role in T7 infection.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalJournal of molecular biology
Volume96
Issue number1
DOIs
StatePublished - Jul 25 1975
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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