The nigrostriatal dopaminergic neurotoxicity of MPTP was prevented in mice in a dose-dependent manner by the monoamine oxidase-B (MAO-B) inhibitor deprenyl. This finding, combined with other observations, points out the important role of MAO-B in the bioactivation of MPTP. In the present study, some comparisons between MPTP and several of its structural analogs will be presented.
|Original language||English (US)|
|Number of pages||9|
|State||Published - May 1988|
All Science Journal Classification (ASJC) codes
- Monoamine oxidase