Subchronic administration of l-DOPA to adult rats with a unilateral 6-hydroxydopamine lesion of dopamine neurons results in a sensitization of enhanced GABA release in the substantia nigra, pars reticulata

Noriko Yamamoto, R. Christopher Pierce, Jean Jacques Soghomonian

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

l-DOPA is the most effective pharmacological agent used for the symptomatic treatment of Parkinson's disease but long-term l-DOPA treatment induces involuntary abnormal movements such as dyskinesias. The present study, using in vivo microdialysis, investigated the effects of a single or subchronic administration of l-DOPA to adult rats with a unilateral 6-OHDA lesion of dopamine neurons on GABA release in the substantia nigra, pars reticulata (SNr). The results indicate that a challenge injection of l-DOPA (50 mg/kg, i.p.) significantly increases GABA levels in the SNr of rats treated with a daily repeated administration of l-DOPA (50 mg/kg, i.p.). Further statistical analysis between groups also showed that extracellular GABA levels were significantly higher in the subchronic l-DOPA group than in the group receiving only one injection of l-DOPA. These results show that the subchronic administration of l-DOPA results in a sensitization of enhanced extracellular GABA levels in the SNr.

Original languageEnglish (US)
Pages (from-to)196-200
Number of pages5
JournalBrain research
Volume1123
Issue number1
DOIs
StatePublished - Dec 6 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • 6-hydroxydopamine
  • Basal ganglia
  • Dyskinesia
  • GABA
  • Levodopa
  • Substantia nigra reticulata

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