Subtherapeutic dicloxacillin levels in a neonate: Possible mechanisms

George J. Schwartz, Thomas Hegyi, Adrian Spitzer

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A neonate treated initially with oxacillin intravenously for two weeks and who was receiving phenobarbital for a seizure disorder subsequently failed to achieve therapeutic levels of orally administered dicloxacillin, even when the dosage was as high as 175 mg/kg/day. Intestinal absorption was documented by high serum peak levels. The low trough levels correlated with a high urinary excretion rate. The possibility that renal tubular transport of dicloxacillin was stimulated by administration of penicillin derivatives (and/or phenobarbital) is suggested, and the need for careful monitoring of serum levels of antibiotics in neonates is emphasized.

Original languageEnglish (US)
Pages (from-to)310-312
Number of pages3
JournalThe Journal of Pediatrics
Issue number2
StatePublished - Jan 1 1976
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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