Suppression of immunity by stress: Effect of a graded series of stressors on lymphocyte stimulation in the rat

Steven E. Keller, Jay M. Weiss, Steven J. Schleifer, Neil E. Miller, Marvin Stein

Research output: Contribution to journalArticlepeer-review

269 Scopus citations

Abstract

In rats a graded series of stressors produced progressively greater suppression of lymphocyte function, as measured by the number of circulating lymphocytes and by phytohemagglutinin stimulation of lymphocytes in whole blood and isolated cultures. This evidence suggests that stress suppresses immunity in proportion to the intensity of the stressor.

Original languageEnglish (US)
Pages (from-to)1397-1400
Number of pages4
JournalScience
Volume213
Issue number4514
DOIs
StatePublished - 1981
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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