Surgical Outcomes and Predictors of Recurrence in Elderly Patients with Meningiomas

Shyamal C. Bir, Subhas Konar, Tanmoy K. Maiti, Bharat Guthikonda, Anil Nanda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background Meningiomas are more prevalent with increasing age, and there is no general consensus of surgical management for this group of tumors. The role of resection and the predictors of recurrence of meningiomas in elderly patients have not been well established. The authors reviewed their experience of surgical resection of these tumors in elderly patients and determined the factors for recurrence. Methods Clinical and radiologic information of 81 elderly patients with meningiomas was retrospectively reviewed. Simpson grading scales were used to evaluate the extent of surgical resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional hazards regression. Results In this study, the recurrence rate in the grades I-II resection group was 10%, whereas in the grades III-IV resection group, the recurrence rate was 46% (P < 0.001). In Cox regression analysis, Simpson grades I-II/complete resection was revealed as a significant predictor of recurrence-free survival (P = 0.002). The hazard ratio for recurrence after grades III-IV resection was 5 times higher than after grades I-II resection. Location, size of the tumor, medical comorbidities, Karnofsky Performance Status, Geriatric Scoring System (GSS) score >16, and repeated resection were identified as predictors of recurrence-free survival after resection of meningiomas. Conclusions Elderly patients with meningiomas having a GSS score >16 and undergoing Simpson grades I-II/gross total resection have low operative morbidity, mortality, and recurrence rates and are less likely to continue on antiepileptic medications. Although complete tumor resection is the goal, the surgical approach should be tailored to each patient depending on the patient's GSS score.

Original languageEnglish (US)
Pages (from-to)251-261
Number of pages11
JournalWorld Neurosurgery
Volume90
DOIs
StatePublished - Jun 1 2016
Externally publishedYes

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Meningioma
Recurrence
Neoplasms
Anticonvulsants
Morbidity
Survival
Mortality

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Bir, Shyamal C. ; Konar, Subhas ; Maiti, Tanmoy K. ; Guthikonda, Bharat ; Nanda, Anil. / Surgical Outcomes and Predictors of Recurrence in Elderly Patients with Meningiomas. In: World Neurosurgery. 2016 ; Vol. 90. pp. 251-261.
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abstract = "Background Meningiomas are more prevalent with increasing age, and there is no general consensus of surgical management for this group of tumors. The role of resection and the predictors of recurrence of meningiomas in elderly patients have not been well established. The authors reviewed their experience of surgical resection of these tumors in elderly patients and determined the factors for recurrence. Methods Clinical and radiologic information of 81 elderly patients with meningiomas was retrospectively reviewed. Simpson grading scales were used to evaluate the extent of surgical resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional hazards regression. Results In this study, the recurrence rate in the grades I-II resection group was 10{\%}, whereas in the grades III-IV resection group, the recurrence rate was 46{\%} (P < 0.001). In Cox regression analysis, Simpson grades I-II/complete resection was revealed as a significant predictor of recurrence-free survival (P = 0.002). The hazard ratio for recurrence after grades III-IV resection was 5 times higher than after grades I-II resection. Location, size of the tumor, medical comorbidities, Karnofsky Performance Status, Geriatric Scoring System (GSS) score >16, and repeated resection were identified as predictors of recurrence-free survival after resection of meningiomas. Conclusions Elderly patients with meningiomas having a GSS score >16 and undergoing Simpson grades I-II/gross total resection have low operative morbidity, mortality, and recurrence rates and are less likely to continue on antiepileptic medications. Although complete tumor resection is the goal, the surgical approach should be tailored to each patient depending on the patient's GSS score.",
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Surgical Outcomes and Predictors of Recurrence in Elderly Patients with Meningiomas. / Bir, Shyamal C.; Konar, Subhas; Maiti, Tanmoy K.; Guthikonda, Bharat; Nanda, Anil.

In: World Neurosurgery, Vol. 90, 01.06.2016, p. 251-261.

Research output: Contribution to journalArticle

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T1 - Surgical Outcomes and Predictors of Recurrence in Elderly Patients with Meningiomas

AU - Bir, Shyamal C.

AU - Konar, Subhas

AU - Maiti, Tanmoy K.

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AU - Nanda, Anil

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N2 - Background Meningiomas are more prevalent with increasing age, and there is no general consensus of surgical management for this group of tumors. The role of resection and the predictors of recurrence of meningiomas in elderly patients have not been well established. The authors reviewed their experience of surgical resection of these tumors in elderly patients and determined the factors for recurrence. Methods Clinical and radiologic information of 81 elderly patients with meningiomas was retrospectively reviewed. Simpson grading scales were used to evaluate the extent of surgical resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional hazards regression. Results In this study, the recurrence rate in the grades I-II resection group was 10%, whereas in the grades III-IV resection group, the recurrence rate was 46% (P < 0.001). In Cox regression analysis, Simpson grades I-II/complete resection was revealed as a significant predictor of recurrence-free survival (P = 0.002). The hazard ratio for recurrence after grades III-IV resection was 5 times higher than after grades I-II resection. Location, size of the tumor, medical comorbidities, Karnofsky Performance Status, Geriatric Scoring System (GSS) score >16, and repeated resection were identified as predictors of recurrence-free survival after resection of meningiomas. Conclusions Elderly patients with meningiomas having a GSS score >16 and undergoing Simpson grades I-II/gross total resection have low operative morbidity, mortality, and recurrence rates and are less likely to continue on antiepileptic medications. Although complete tumor resection is the goal, the surgical approach should be tailored to each patient depending on the patient's GSS score.

AB - Background Meningiomas are more prevalent with increasing age, and there is no general consensus of surgical management for this group of tumors. The role of resection and the predictors of recurrence of meningiomas in elderly patients have not been well established. The authors reviewed their experience of surgical resection of these tumors in elderly patients and determined the factors for recurrence. Methods Clinical and radiologic information of 81 elderly patients with meningiomas was retrospectively reviewed. Simpson grading scales were used to evaluate the extent of surgical resection. Statistical analysis was conducted using Kaplan-Meier curves and Cox proportional hazards regression. Results In this study, the recurrence rate in the grades I-II resection group was 10%, whereas in the grades III-IV resection group, the recurrence rate was 46% (P < 0.001). In Cox regression analysis, Simpson grades I-II/complete resection was revealed as a significant predictor of recurrence-free survival (P = 0.002). The hazard ratio for recurrence after grades III-IV resection was 5 times higher than after grades I-II resection. Location, size of the tumor, medical comorbidities, Karnofsky Performance Status, Geriatric Scoring System (GSS) score >16, and repeated resection were identified as predictors of recurrence-free survival after resection of meningiomas. Conclusions Elderly patients with meningiomas having a GSS score >16 and undergoing Simpson grades I-II/gross total resection have low operative morbidity, mortality, and recurrence rates and are less likely to continue on antiepileptic medications. Although complete tumor resection is the goal, the surgical approach should be tailored to each patient depending on the patient's GSS score.

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