Sustained stimulation of aldosterone production by angiotensin II is potentiated by nickel

A. Spat, I. Balla, T. Balla, P. Enyedi, G. Hajnoczky, T. Rohacs

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7 Scopus citations


Angiotensin-induced aldosterone production by superfused adrenal glomerulosa cells was potentiated by Ni2+ (0.1 mM), added either at the onset of stimulation with angiotensin II or 1 h later. Nickel did not influence the effect of adrenocorticotropic hormone or potassium on aldosterone production. Nickel failed to modify angiotensin-induced changes in phospholipid metabolism or the formation of inositol phosphates and slightly reduced the enhancement of 45Ca influx. Uptake of Ni2+ into glomerulosa cells was increased by depolarization in a dihydropyridine-insensitive manner. Because nickel selectively potentiates the sustained phase of the response to a calcium-mobilizing hormone, it may serve as a suitable tool in elucidating the signal transduction process during the sustained phase of stimulation.

Original languageEnglish (US)
Pages (from-to)E555-E561
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number4 21-4
StatePublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


  • adrenocorticotropic hormone
  • calcium-mobilizing hormones
  • cobalt
  • dihydropyridines
  • glomerulosa cell
  • inositol trisphosphate
  • nickel uptake
  • potassium


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