Symmetry invariance for adapting biological systems

Oren Shoval, Uri Alon, Eduardo Sontag

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

For a general class of dynamical systems, this paper presents a necessary and sufficient characterization of invariance of transient responses to symmetries in inputs. A particular example of this property, scale-invariance or "fold-change detection" (FCD), has been shown to be exhibited in biological sensory systems ranging from bacterial chemotaxis pathways to signal transduction mechanisms in eukaryotes. The characterization is in terms of a notion of equivariance and amounts to the solvability of an associated partial differential equation. For several simple system motifs that are recurrent in biology, the solvability criterion may be checked explicitly.

Original languageEnglish (US)
Pages (from-to)857-886
Number of pages30
JournalSIAM Journal on Applied Dynamical Systems
Volume10
Issue number3
DOIs
StatePublished - 2011

All Science Journal Classification (ASJC) codes

  • Analysis
  • Modeling and Simulation

Keywords

  • Fold-detection
  • Input transformations
  • Scale-invariance

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