Synapse Formation and Memory

B. Leuner, T. J. Shors

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Cellular mechanisms of learning and memory have long been assumed to involve alterations in structural plasticity. Recent evidence has shown that: (1) numerous factors which alter synaptic structure also influence learning and memory; (2) modifications in structural synaptic plasticity occur following long-term potentiation (LTP), a cellular model for memory, as well as after learning itself; and (3) some disorders characterized by cognitive deficits are accompanied by abnormalities in synaptic number and architecture. These data support the notion that synaptic growth and remodeling are dynamic processes that may provide an anatomical substrate for the formation and storage of memories in the adult brain.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Behavioral Neuroscience
PublisherElsevier Inc.
Number of pages7
ISBN (Electronic)9780080914558
ISBN (Print)9780080453965
StatePublished - Jan 1 2010

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)


  • Cortex
  • Dendritic spine
  • Environmental enrichment
  • Estrogen
  • Experience
  • Eyeblink conditioning
  • Golgi
  • Hippocampus
  • LTP
  • Learning
  • NMDA
  • Plasticity
  • Postsynaptic density
  • Sex differences
  • Stress


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