Synapse Formation and Memory

B. Leuner; T. J. Shors

doi:10.1016/B978-0-08-045396-5.00243-8

Synapse Formation and Memory

B. Leuner, T. J. Shors

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Cellular mechanisms of learning and memory have long been assumed to involve alterations in structural plasticity. Recent evidence has shown that: (1) numerous factors which alter synaptic structure also influence learning and memory; (2) modifications in structural synaptic plasticity occur following long-term potentiation (LTP), a cellular model for memory, as well as after learning itself; and (3) some disorders characterized by cognitive deficits are accompanied by abnormalities in synaptic number and architecture. These data support the notion that synaptic growth and remodeling are dynamic processes that may provide an anatomical substrate for the formation and storage of memories in the adult brain.

Original language	English (US)
Title of host publication	Encyclopedia of Behavioral Neuroscience
Publisher	Elsevier Inc.
Pages	349-355
Number of pages	7
ISBN (Electronic)	9780080914558
ISBN (Print)	9780080453965
DOIs	https://doi.org/10.1016/B978-0-08-045396-5.00243-8
State	Published - Jan 1 2010

All Science Journal Classification (ASJC) codes

General Medicine
General Neuroscience

Keywords

Cortex
Dendritic spine
Environmental enrichment
Estrogen
Experience
Eyeblink conditioning
Golgi
Hippocampus
LTP
Learning
NMDA
Plasticity
Postsynaptic density
Sex differences
Stress

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10.1016/B978-0-08-045396-5.00243-8

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abstract = "Cellular mechanisms of learning and memory have long been assumed to involve alterations in structural plasticity. Recent evidence has shown that: (1) numerous factors which alter synaptic structure also influence learning and memory; (2) modifications in structural synaptic plasticity occur following long-term potentiation (LTP), a cellular model for memory, as well as after learning itself; and (3) some disorders characterized by cognitive deficits are accompanied by abnormalities in synaptic number and architecture. These data support the notion that synaptic growth and remodeling are dynamic processes that may provide an anatomical substrate for the formation and storage of memories in the adult brain.",

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AB - Cellular mechanisms of learning and memory have long been assumed to involve alterations in structural plasticity. Recent evidence has shown that: (1) numerous factors which alter synaptic structure also influence learning and memory; (2) modifications in structural synaptic plasticity occur following long-term potentiation (LTP), a cellular model for memory, as well as after learning itself; and (3) some disorders characterized by cognitive deficits are accompanied by abnormalities in synaptic number and architecture. These data support the notion that synaptic growth and remodeling are dynamic processes that may provide an anatomical substrate for the formation and storage of memories in the adult brain.

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KW - Dendritic spine

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KW - Estrogen

KW - Experience

KW - Eyeblink conditioning

KW - Golgi

KW - Hippocampus

KW - LTP

KW - Learning

KW - NMDA

KW - Plasticity

KW - Postsynaptic density

KW - Sex differences

KW - Stress

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BT - Encyclopedia of Behavioral Neuroscience

PB - Elsevier Inc.

ER -

Synapse Formation and Memory

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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