Synchronized induction in bFGF and Cdk2 during gastric ulcer healing

B. L. Slomiany, J. Piotrowski, A. Slomiany

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The processes of gastric mucosal repair are regulated by growth factors triggering the signals for cell cycle progression. We examined the expression of gastric mucosal basic fibroblast factor (bFGF) and cyclin dependent kinase (p34Cdk2) at different stages of chronic ulcer healing. The results of assays revealed that ulcer healing was accompanied by an increase in mucosal expression of bFGF and Cdk2. A significant induction in bFGF and Cdk2 occurred by the 2nd day of ulcer healing, reached the respective maximums of 2.3- and 2.2-fold increase by the 4th day of healing, and remained still elevated (20%) on the 14th day when the ulcer was essentially healed. The results demonstrate a synchronized induction in bFGF and cell cycle regulatory kinase, Cdk2, with ulcer healing.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalBiochemistry and Molecular Biology International
Volume40
Issue number2
DOIs
StatePublished - 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Keywords

  • Cdk2
  • Expression
  • Gastric ulcer
  • Healing
  • bFGF

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