Syntheses of arnottin i and arnottin II

Matthew J. Moschitto, David R. Anthony, Chad A. Lewis

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Short total syntheses of arnottin I and II were accomplished in 5 and 6 steps, respectively. A sesamol-benzyne cycloaddition with a 3-furyl-benzoate followed by regiospecific lactonization provided rapid, large-scale access to the core of arnottin I. Saponification of arnottin I and hypervalent iodide mediated spirocyclization provided an efficient and direct preparation of racemic arnottin II.

Original languageEnglish (US)
Pages (from-to)3339-3342
Number of pages4
JournalJournal of Organic Chemistry
Volume80
Issue number6
DOIs
StatePublished - Mar 20 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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