Synthesis and anticancer activity study of curcumin-related compounds containing benzyl piperidone

Daiying Zhou, Suqing Zhao, Xi Zheng, Zhiyun Du, Kun Zhang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Sixteen curcumin-related compounds containing benzyl piperidone were synthesized and evaluated for their anticancer activity by the MTT assay towards cultured prostate cancer (PC-3), pancreatic cancer (BxPC-3), colon cancer (HT-29), and lung cancer (H1299) cells. Compounds A1 and B3 exhibited potent growth inhibitory effects against these cells in culture. The IC50 values of these compounds were lower than 1 μM in all four cell lines.

Original languageEnglish (US)
Pages (from-to)524-529
Number of pages6
JournalJournal of Chinese Pharmaceutical Sciences
Volume24
Issue number8
DOIs
StatePublished - 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Anticancer activity
  • Curcumin-related compounds
  • Synthesis

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