Abstract
Sixteen curcumin-related compounds containing benzyl piperidone were synthesized and evaluated for their anticancer activity by the MTT assay towards cultured prostate cancer (PC-3), pancreatic cancer (BxPC-3), colon cancer (HT-29), and lung cancer (H1299) cells. Compounds A1 and B3 exhibited potent growth inhibitory effects against these cells in culture. The IC50 values of these compounds were lower than 1 μM in all four cell lines.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 524-529 |
| Number of pages | 6 |
| Journal | Journal of Chinese Pharmaceutical Sciences |
| Volume | 24 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2015 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
Keywords
- Anticancer activity
- Curcumin-related compounds
- Synthesis